I wasn't beliving this when it happened the other day, but it did.
My signals were acting eratically and then just stopped altogether. I still had hazard flashers and NO back up lites. BU Lites and Turn Sigs are on same fuse. I had replaced it several times(4) and it had blown each time. I was ready to pull the steering wheel after reading some advice here on the forum.
Prior to that; I thot I should do basic voltage checks, on all of my lites_Back up, brake,tail. Voltage checked out fine, then did continuity on bulbs, all checked out,--However, on right rear BU lite was a thin coat of some clear substance,(Go ahead and laugh, but I can only compare it to KY Jelly) on the bulb!!

cleaned it off with iso-alcohol and replaced the fuse and it has been good since.
Something to try before you get hip deep in quick sand!;
Good Luck
Majyc